Editing DNA vs. Evolution. Change vs. One. A battle lost before it even starts.

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Octopus, squid, and cuttlefish are famous for engaging in complex behavior, from unlocking an aquarium tank and escaping to instantaneous skin camouflage to hide from predators. A new study suggests their evolutionary path to neural sophistication includes a novel mechanism: Prolific RNA editing at the expense of evolution in their genomic DNA.

In contrast, RNA editing in the more primitive cephalopod Nautilus and in the mollusk Aplysia occurs at orders of magnitude lower levels than in the coleoids, they found.

The scientists discovered a striking trade-off between high levels of RNA recoding and genomic evolution in these cephalopods. The most common form of RNA editing is carried out by ADAR enzymes, which require large structures (dsRNA) flanking the editing sites. These structures, which can span hundreds of nucleotides, are conserved in the coleoid genome along with the editing sites themselves. The genetic mutation rate in these flanking regions is severely depressed, the team reported. “The conclusion here is that in order to maintain this flexibility to edit RNA, the coleoids have had to give up the ability to evolve in the surrounding regions – a lot,” Rosenthal says. “Mutation is usually thought of as the currency of natural selection, and these animals are suppressing that to maintain recoding flexibility at the RNA level.” (1)

Evolution is one more example of the antiphasis embedded in the cosmos we experience with our senses. It calls for constant change and yet, the mechanism of the change itself must be stable in order to achieve that. More than ever, we have evidence of contradictions which point to only one possible solution: that the contradictions are falsely projected by a false image we have of the cosmos as a whole.

Seek stability, if you want change.

Seek change, if you seek stability…

The world is One, and thus changing continuously.

The world changes continuously and that is the best evidence that it is not…

Author: skakos

Spiros Kakos (or Spyros Kakos or Spyridon Kakos) [Σπύρος Κάκος] is a thinker located in Athens, Greece. He has been the Chief Editor of Harmonia Philosophica since its inception. Spiros has a diploma in Chemical Engineering, an MSc in Advanced Materials' Technology, an MBA in Decisions' Science, a phD in the use of conductive polymers in PCB industry and is still learning. He also worked as a technical advisor and a researcher in the Advanced Materials sector for many years in the past. In his free time he develops software solutions and contributes to the open source community. He is the creator of Huo Chess, one of the smallest micro-chess programs ever that is perfect for educational purposes. He believes that science and religion are two sides of the same coin and is profoundly interested in Religion and Science philosophy, as well as the philosophy of the irrational. His philosophical work is mainly concentrated on an effort to free thinking of "logic" and reconcile all philosophical opinions under the umbrella of the "One" that Parmenides - one of the first thinkers - visualized. Since our thought is dictated by our assumptions, the only way to free it and know cosmos as it is, is to think irrationally and destroy everything we have built. The "Harmonia Philosophica" articles program is the tool that will accomplish that. Life's purpose is to be defeated by greater things. And the most important things in life are illogical. We must fight the dogmatic belief in "logic" if we are to stay humans. We should stop thinking in order to think. Credo quia absurdum! View all posts by skakos

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