Recycling… Identity issues…

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The secret to a long life? For worms, a cellular recycling protein is key. Scientists at Sanford Burnham Prebys Medical Discovery Institute have shown that worms live longer lives if they produce excess levels of a protein, p62, which recognizes toxic cell proteins that are tagged for destruction. The discovery, published in Nature Communications, could help uncover treatments for age-related conditions, such as Alzheimer’s disease, which are often caused by accumulation of misfolded proteins.

“Research, including our own, has shown that lifespan can be extended by enhancing autophagy – the process cells use to degrade and recycle old, broken and damaged cell components”, says Malene Hansen, Ph.D., a professor in the Development, Aging and Regeneration Program at Sanford Burnham Prebys and senior author of the study. “Prior to this work, we understood that autophagy as a process was linked to aging, but the impact of p62, a selective autophagy protein, on longevity was unknown”. (1)

There you go.

Recycle old material and you will live longer.

But will that new ship built with new material be the same as the old ship which started the sail?

Will you recognize your mother when you get back home?

Questions we do not care about.

Because unfortunately modern man has chosen not to return home…

And on that new ship we set sails.

All into the dark sea.

Storm raging. Thunders and rain.

You believe these are obstacles toward your goal.

But they are just a calling back home…

Where our old ship is waiting.

To carry us where we need to go…

Cowards… Seeking meaning in life…

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Over the last three decades, meaning in life has emerged as an important question in medical research, especially in the context of an aging population. A recent study by researchers at University of California San Diego School of Medicine found that the presence of and search for meaning in life are important for health and well-being, though the relationships differ in adults younger and older than age 60.

“Many think about the meaning and purpose in life from a philosophical perspective, but meaning in life is associated with better health, wellness and perhaps longevity,” said senior author Dilip V. Jeste, MD, senior associate dean for the Center of Healthy Aging and Distinguished Professor of Psychiatry and Neurosciences at UC San Diego School of Medicine. “Those with meaning in life are happier and healthier than those without it.” (1)

Find meaning in life.

And you will live a longer life.

But you will have missed its meaning.

For the meaning of life is not pleasure.

For the meaning of existence is pain.

And Being is full of it.

Search your soul.

Coward!

Yes, you seek life.

But only because it entails death…

Domesticating our self…

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Domestic animals’ cuteness and humans’ relatively flat faces may be the work of a gene that controls some important developmental cells, a study of lab-grown human cells suggests.

Some scientists are touting the finding as the first real genetic evidence for two theories about domestication. One of those ideas is that humans domesticated themselves over many generations, by weeding out hotheads in favor of the friendly and cooperative (SN: 7/6/17). As people supposedly selected among themselves for tameness traits, other genetic changes occurred that resulted in humans, like other domesticated animals, having a different appearance than their predecessors. Human faces are smaller, flatter and have less prominent brow ridges than Neanderthal faces did, for instance. (1)

We were wild.

Then we domesticated ourselves.

Only to survive.

And live longer.

And create philosophy.

And find out that we die.

And in the face of death we became rough.

And out of fear of death we became wild…

Longing for peace of mind.

Longing for life.

Look at the lion.

Wandering alone.

Seeking chaos.

Seeking blood.

Watch the Moon.

Die in its claws.

Watch the Sun.

(Its the only thing that can go dark…)

The forest will be empty soon.

And the lonely (wild) sound of crickets will terrify you…

Free access to… microbes! Free access to… life! 

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Poverty increases the risk for numerous diseases by limiting people’s access to healthy food, environments and stress-free conditions. In a new essay published November 26 in the open-access journal PLOS Biology, Suzanne Ishaq and colleagues at the University of Oregon, argue that poverty also compromises health by creating unequal access to beneficial microorganisms.  

People living in low-income communities lack many of the factors that help promote healthy microbiomes, such as access to fresh food, clean air and water, adequate pre- and postnatal care, and healthy indoor environments. Scientists have linked low microbial diversity to poor health, including obesity and associated metabolic problems and multiple mental health and psychiatric disorders. These problems may disproportionally affect poorer individuals and compound existing health disparities. (1

We need access to microbes if we are to have health. 

Yes, we need access to death, if we are to sustain life. 

We need access to the void of knowledge, if we are to appreciate ignorance. 

We need access to our meaningless existence, if we are to appreciate the meaning of being. 

The day is burning now. 

Look at the Moon. 

Do you remember? 

That was the first time you glanced at the Sun… 

Reverse evolution 2.

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Turtle ant soldiers scuttle to and from sporting shiny, adorably oversized heads, which they use to block the entrances of their nests — essentially acting as living doors.

Not all heads are shaped alike: some soldiers have ones that resemble manhole covers and perfectly seal tunnel entrances. Others have square heads, which they assemble into multi-member blockades reminiscent of a Spartan army’s overlapping shields. TheThe shape and size of a turtle-ant soldier’s head is dictated by the type of tunnel the species in question occupies. The ants don’t dig the tunnels themselves, but move into those excavated by wood-boring beetles. And since a hand-me-down tunnel might be too big or too small, Kronauer says, the ants diversify rapidly to be able to occupy it.

To examine the evolutionary journey of various head shapes, the researchers grouped 89 species of turtle ants based on whether soldiers sported a square, dome, disc, or dish-shaped head. They also included a group of turtle-ant species that don’t have soldiers. They then examined the evolutionary relationships among these groups using the species’ genetic information, which they had previously gathered.

If evolution was a one-way path, the first turtle ants that appeared some 45 million years ago should have lacked soldiers altogether, then gradually evolved toward specialization — starting with the generalist, square-headed soldiers, all the way to those with highly-tailored dish heads.

But the new analysis suggests that this was not the case. Instead, the oldest common ancestor the researchers could trace likely had a square head. That ancestor went on to form a range of species, from ones with no soldiers at all to others with different levels of specialization. In some cases, more specialist species reversed direction over time, evolving back into more generalist head shapes. (1)

But you cannot adapt!

Unless you have already done so…

At the end, even the trees will die.

And your big question will be answered.

And as you leave your last breath.

Right next to some dead ants running.

A smile will spread across your face.

I will never change!

I have adapted!

I will not live for ever!

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