Some tissue types give rise to human cancers millions of times more often than other tissue types. Although this has been recognized for more than a century, it has never been explained. Here, we show that the lifetime risk of cancers of many different types is strongly correlated (0.81) with the total number of divisions of the normal self-renewing cells maintaining that tissue’s homeostasis. These results suggest that only a third of the variation in cancer risk among tissues is attributable to environmental factors or inherited predispositions. The majority is due to “bad luck,” that is, random mutations arising during DNA replication in normal, noncancerous stem cells. This is important not only for understanding the disease but also for designing strategies to limit the mortality it causes. (1)
Leave everything to luck.
And you will be unlucky.
Stop believing in luck and the odds will turn in your favor…
It doesn’t matter what you will achieve.
The whole world is Will.
if you want something,
it has already happened…
Let go in the flow.
We all start from the same point.
We all end up in the same point.
Does it matter how?
The dices have been thrown.
Everything will happen.
Eat the dice.